Ko te mate a Alzheimer, he mate pūnaha io e ahu whakamua ana, ka puta mai i roto i ngā tohu pēnei i te ngaronga o te mahara, te aphasia, te agnosia, me te ngoikore o te mahi whakahaere. I ngā wā o mua, i whakawhirinaki ngā tūroro ki ngā rongoā hei whakaora i ngā tohu. Heoi, nā ngā herenga me ngā pānga taha pea o ēnei rongoā, kua tahuri ngā kairangahau ki te whakaora whakaahua kore-whakaeke, ā, kua tutuki i a rātou ngā whanaketanga nui i ngā tau tata nei.
Nō nā tata nei, i kitea e tētahi rōpū i arahina e Ahorangi Zhou Feifan o te Kareti Hangarau Hauora o Te Whare Wānanga o Hainan, ka taea e te phototherapy whakawhiti angaanga kore-pā te whakamama i ngā tohu mate me te whakarei ake i ngā pūkenga hinengaro i roto i ngā kiore kua koroheketia me ngā kiore e pangia ana e te mate Alzheimer. Ko tēnei kitenga hou, i whakaputaina i roto i te puka Nature Communications, he rautaki whai hua mō te whakahaere i ngā mate neurodegenerative.
Te Mārama ki te Mate o Alzheimer
Kāore anō kia mārama te tino pūtake o te mate a Alzheimer, engari ko tōna āhua he whakakotahitanga pūmua beta-amyloid rerekē me ngā hononga neurofibrillary, ka hua ake te ngoikore o ngā neuron me te hekenga o te hinengaro. Ko te roro, te okana tino kaha o te tinana ki te mahi pākia, ka whakaputa i ngā para pākia nui i te wā e mahi ana ngā io. Ko te nui rawa o te kohikohinga o ēnei para ka kino ki ngā neuron, ka hiahiatia he tango pai mā te pūnaha lymphatic.
He mea nui ngā oko toto lymphatic meningeal mō te rerenga wai o te pūnaha io matua, ā, he mea nui ēnei ki te whakakore i ngā pūmua beta-amyloid paitini, ngā para pākia o te tinana, me te whakahaere i te mahi ārai mate, ā, ka waiho hei ūnga mō te maimoatanga.
Te Pānga o te Whakaahua-whakaora ki te Mate a Alzheimer
I whakamahia e te tīma a Ahorangi Zhou he taiaho tata-infrared 808 nm mō ngā wiki e whā o te phototherapy transcranial kore-pā ki ngā kiore kua koroheke me ngā kiore kua pangia e te mate a Alzheimer. Nā tēnei maimoatanga i whakarei ake te mahi a ngā pūtau endothelial lymphatic meningeal, i whakapai ake te rerenga lymphatic, ā, i te mutunga i whakamama i ngā tohu mate me te whakapai ake i ngā mahi hinengaro i roto i ngā kiore.
Te Whakatairanga i te Mahi Neuronal mā te Phototherapy
Ka taea e te rongoā-pūtau te whakarei ake me te whakapai ake i te mahi a ngā pūtau io mā roto i ngā momo tikanga. Hei tauira, he mahi nui tā te tukanga ārai mate i roto i te mate o Alzheimer. E whakaatu ana ngā rangahau hou ka taea e te hihi laser matomato 532 nm te whakanui ake i te mahi a ngā pūtau ārai mate, te whakaoho i ngā tikanga ā-roto i roto i ngā pūtau io pokapū hohonu, te whakapai ake i te mate wareware toto, me te whakarei ake i ngā nekehanga rere toto me ngā tohu haumanu i roto i ngā tūroro Alzheimer. Kua whakaatuhia e te hihi laser matomato tuatahi ngā whakapainga nui i roto i te matotoru o te toto, te matotoru o te plasma, te whakakotahitanga o ngā pūtau toto whero, me ngā whakamātautau neuropsychological.
Mā te whakaora rama whero me te rama pūwhero (whakaahua koiora) e whakamahia ana ki ngā taha o te tinana (tuara me ngā waewae) ka taea te whakahohe i ngā pūtau ārai mate, i ngā tikanga tiaki ā-roto rānei o ngā pūtau take, ka whai wāhi ki te oranga o ngā pūtau io me te whakaaturanga ira whai hua.
He tukanga mate nui anō hoki te kino o te waikura i roto i te whanaketanga o te mate a Alzheimer. E whakaatu ana ngā rangahau ka taea e te hihi o te rama whero te whakanui ake i te mahi ATP pūtau, te whakaoho i te nekehanga pākia mai i te glycolysis ki te mahi mitochondrial i roto i ngā microglia mumura e pāngia ana e te beta-amyloid oligomeric, te whakarei ake i ngā taumata microglia anti-inflammatory, te whakaiti i ngā cytokines pro-inflammatory, me te whakahohe i te phagocytosis hei ārai i te mate neuronal.
Ko te whakapai ake i te mataara, te mōhio, me te aro tonu tētahi atu tikanga whai hua hei whakapai ake i te kounga o te oranga o ngā tūroro a Alzheimer. Kua kitea e ngā kairangahau ko te pānga ki te mārama kikorangi poto-roa he pānga pai ki te mahi hinengaro me te whakahaere i ngā kare ā-roto. Ka taea e te whitinga mārama kikorangi te whakatairanga i te mahi ara iahiko io, te awe i te mahi a te acetylcholinesterase (AchE) me te choline acetyltransferase (ChAT), ā, ka whakapai ake i ngā pūkenga ako me te mahara.
Ngā Pānga Pai o te Whakaahua-whakaora ki ngā Neuron Roro
Kei te piki haere te maha o ngā rangahau whai mana e whakaū ana i ngā pānga pai o te phototherapy ki te mahi a ngā neuron o te roro. Ka āwhina i te whakahohe i ngā tikanga tiaki ā-roto o ngā pūtau ārai mate, ka whakatairanga i te whakaaturanga ira oranga o ngā neuron, ā, ka whakataurite i ngā taumata momo hāora tauhohe o te mitochondrial. Mā ēnei kitenga ka whakatū he turanga pakari mō ngā tono haumanu a te phototherapy.
I runga i ēnei māramatanga, i whakahaerehia e te MERICAN Optical Energy Research Center, i te mahi tahi me tētahi tīma Tiamana me ngā whare wānanga maha, rangahau, me ngā whare hauora, tētahi rangahau e pā ana ki ngā tāngata 30-70 tau te pakeke me te ngoikore o te hinengaro, te heke o te mahara, te iti o te mārama me te whakatau, me te ngoikore o te kaha ako. I piri ngā kaiuru ki ngā aratohu kai me te oranga hauora i a rātou e whiwhi ana i te phototherapy i roto i te whare hauora o MERICAN, me ngā momo rongoā me ngā horopeta ōrite.
I muri i ngā marama e toru o ngā whakamātautau hinengaro-pūnaha, ngā whakamātautau āhua hinengaro, me ngā aromatawai hinengaro, i whakaatuhia e ngā hua he whakapainga nui i roto i ngā kaute MMSE, ADL, me te HDS i waenga i ngā kaiwhakamahi whakaora whakaahua i roto i te whare hauora. I pāngia hoki ngā kaiuru e te aro tirohanga pai ake, te kounga moe, me te whakaiti i te manukanuka.
E whakaatu ana ēnei kitenga he pai pea te whakamahi i te whakaahua hei rongoā tautoko hei whakahaere i te mahi a ngā pūtau roro, hei whakaiti i te mumura o te roro me ngā mate e pā ana, hei whakapai ake i te hinengaro, me te whakarei ake i te mahara. Heoi anō, ka huaki i ngā huarahi hou mō te whakaahua hei huarahi rongoā ārai mate.
